Which of the following symptoms may indicate Cushing's disease?

Cushing's disease is primarily caused by an excess of cortisol in the body, often due to a pituitary tumor that stimulates adrenal gland activity. One of the hallmark symptoms of this condition is fatigue, which occurs in many patients as their bodies struggle to maintain normal function under the influence of high cortisol levels. This fatigue can be overwhelming and is often accompanied by a general sense of being unwell or experiencing decreased energy levels, which is a significant concern for those suffering from Cushing's disease.

The other symptoms listed do not typically indicate Cushing's disease. For example, weight loss is more commonly associated with conditions that cause increased metabolism or chronic illness rather than the weight gain often seen in Cushing's. A goiter is related to thyroid dysfunction, not adrenal or pituitary problems associated with Cushing's disease. Joint pain can occur due to various reasons but is not a specific symptom of Cushing's; rather, individuals with Cushing's often experience joint issues secondary to obesity or changes in muscle mass rather than the condition itself. Therefore, fatigue is a recognizable and relevant symptom associated with Cushing's disease, making it the correct choice.