Which condition is indicated by albinism and vitiligo?

Albinism and vitiligo are both conditions characterized by a reduction or absence of melanin, the pigment responsible for coloring the skin, hair, and eyes. Albinism is a genetic condition leading to a complete lack of melanin production, while vitiligo is an acquired condition where patches of skin lose melanin due to the autoimmune destruction of melanocytes (the cells that produce melanin).

The term "depigmentation" specifically refers to the loss of pigment in the skin and is a key feature in both of these conditions. In a medical context, endogenous refers to conditions arising from within the body, as seen in genetic disorders like albinism and autoimmune diseases like vitiligo.

The other choices do not appropriately describe the conditions in question. Melanosis refers to an abnormal increase in melanin, which is the opposite of what albinism and vitiligo exhibit. A pustule is a small, pus-filled blister or lesion, and a granuloma is a type of inflammation characterized by a collection of immune cells, neither of which pertains to the pigmentary changes observed in albinism or vitiligo. Therefore, the indication of both albinism and vitiligo as conditions of depigmentation validates the