What primarily causes the symptoms associated with Cushing's disease?

The symptoms associated with Cushing's disease are primarily caused by excess cortisol in the body. Cushing's disease is a specific form of Cushing's syndrome that is usually caused by a tumor in the pituitary gland, which leads to an overproduction of adrenocorticotropic hormone (ACTH). This hormone then stimulates the adrenal glands to produce more cortisol.

Cortisol is a steroid hormone that plays a crucial role in various bodily functions, including metabolism and stress response. When there is an excess of cortisol, it can lead to a range of symptoms, including weight gain, high blood pressure, skin changes, and emotional disturbances. This condition exemplifies how hormonal imbalances can lead to specific clinical presentations and underscores the importance of cortisol in maintaining homeostasis within the body.

Other hormones, such as thyroid hormone, adrenaline, and insulin, do have roles in various physiological processes, but they are not directly related to the symptomatology observed in Cushing's disease. Understanding the role of cortisol helps in recognizing the impact of hormonal disorders on overall health.