What is the diagnostic sign indicative of Hodgkin's disease?

What is the diagnostic sign indicative of Hodgkin's disease?

• A. mott cells
• B. negri bodies
• C. aschoff's bodies
• D. reed-sternburg cells

Answer: (D)

The diagnostic sign indicative of Hodgkin's disease is the presence of Reed-Sternberg cells. These cells are large, abnormal lymphocytes that can be identified under a microscope in tissue samples taken from lymph nodes. The presence of Reed-Sternberg cells is considered a hallmark feature of Hodgkin's lymphoma, which distinguishes it from other types of lymphomas. In pathology, the identification of Reed-Sternberg cells provides critical evidence for diagnosing Hodgkin's disease, guiding treatment decisions and patient prognosis. They are often described as "owl-eyed" due to their distinctive appearance, which helps pathologists in making an accurate diagnosis. This characteristic is significant because it directly correlates with the behavior and classification of the disease, leading to appropriate management strategies. While other structures such as mott cells, Negri bodies, and Aschoff's bodies are associated with different diseases or conditions, they do not pertain to Hodgkin's disease, emphasizing the unique nature of Reed-Sternberg cells in identifying this specific lymphoma.

The diagnostic sign indicative of Hodgkin's disease is the presence of Reed-Sternberg cells. These cells are large, abnormal lymphocytes that can be identified under a microscope in tissue samples taken from lymph nodes. The presence of Reed-Sternberg cells is considered a hallmark feature of Hodgkin's lymphoma, which distinguishes it from other types of lymphomas.

In pathology, the identification of Reed-Sternberg cells provides critical evidence for diagnosing Hodgkin's disease, guiding treatment decisions and patient prognosis. They are often described as "owl-eyed" due to their distinctive appearance, which helps pathologists in making an accurate diagnosis. This characteristic is significant because it directly correlates with the behavior and classification of the disease, leading to appropriate management strategies.

While other structures such as mott cells, Negri bodies, and Aschoff's bodies are associated with different diseases or conditions, they do not pertain to Hodgkin's disease, emphasizing the unique nature of Reed-Sternberg cells in identifying this specific lymphoma.